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KMID : 0370220070510060409
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Yakhak Hoeji
2007 Volume.51 No. 6 p.409 ~ p.414
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Improvement of Memory Impairment by L-Theanine Through Inhibition of Acetylcholinesterase Activity in Mice
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Yuk Dong-Yeon
Park Sang-Ki
Kim Tae-Il
Park Hyoung-Kook
Yoon Yeo-Kyeung
Hong Jin-Tae
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Abstract
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Acetylcholinesterase (AChE) plays a role in the progression of Alzheimer’s disease (AD). In this study, we examined the improving effect of L-theanine, a major amino acid in Japanese green tea (Camellia sinensis) on the scopolamine (1 mg/kg/mouse)-induced memory dysfunction in mice. Treatment with L-theanine (2, 4 mg/kg/mouse p.o.) in the drinking water for 7 days reversed the scopolamine-induced latency time and distance in the water maze test, latency time in the passive avoidance test, and inhibited AChE activity. This study suggests that L-theanine may be a useful agent for prevention of progression of AD.
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KEYWORD
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theanine, Alzheimer’s disease, memory, acetylcholinesterase
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